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KMID : 0364820180540030222
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Korean Journal of Microbiology
2018 Volume.54 No. 3 p.222 ~ p.227
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CD1b in immature dendritic cells acquires increased phagocytotic function
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Liew Hyun-Jeong
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Abstract
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Mycobacterium tuberculosis (MTB)-originated lipid antigen ispresented on the antigen-presenting cell surface with CD1b.
When monocyte-derived dendritic cells phagocytosed MTBH37Rv (Multiplicity of infection 10, infectivity: 46.89%), theCD1b expression level decreased slowly. Since this was just alive MTB-mediated phenomenon, it was not detected fromheat-killed MTB or mycolic acid, which is a unique antigen ofMTB. We confirmed that the phosphorylation of CD1b moleculesusing 2D electrophoresis with staining could phosphorylateand induce the presentation of the lipid antigen using thephagocytosis assay.
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KEYWORD
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Mycobacterium tuberculosis (MTB), CD1b, phagocytosis, phosphorylation, two-dimensional electrophoresis
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